IPMK: A versatile regulator of nuclear signaling events

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Inositol-derived metabolites (e.g., phosphoinositides and inositol polyphosphates) are key second messengers that are essential for controlling a wide range of cellular events. Inositol polyphosphate multikinase (IPMK) exhibits complex catalytic activities that eventually yield water-soluble inositol polyphosphates (e.g., IP4 and IP5) and lipid-bound phosphatidylinositol 3,4,5-trisphosphate. A series of recent studies have suggested that IPMK may be a multifunctional regulator in the nucleus of mammalian cells. In this review, we highlight the novel modes of action of IPMK in transcriptional and epigenetic regulation, and discuss its roles in physiology and disease.
Publisher
ELSEVIER SCIENCE INC
Issue Date
2016-05
Language
English
Citation

ADVANCES IN BIOLOGICAL REGULATION, v.61, pp.25 - 32

ISSN
2212-4926
DOI
10.1016/j.jbior.2015.11.005
URI
http://hdl.handle.net/10203/214524
Appears in Collection
BS-Journal Papers(저널논문)
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