Facile and sensitive detection of influenza viruses using SERS antibody probes

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It is highly important to identify influenza viruses rapidly and accurately for the prevention of future pandemic outbreaks. We developed an easy and sensitive influenza virus detection method using surface-enhanced Raman scattering (SERS) antibody probes. The SERS antibody probes can be prepared easily by mixing Au nanoparticles, gold binding peptide-protein G, and antibodies without complicated chemical or biological reactions. They also retain the optimal conformation for the antibody's interaction with Influenza A/CA/07/2009 (pH1N1), allowing us to detect pH1N1 sensitively and selectively. This method provides a detection limit of 4.1 x 10(3) TCID per mL and is highly selective for pH1N1. We anticipate that this method can be useful in a wide range of immunoassays
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2016
Language
English
Article Type
Article
Keywords

ENHANCED RAMAN-SCATTERING; IMMUNOGOLD NANOPARTICLES; RAPID DETECTION; SURFACE; IMMUNOASSAY; ANTIGEN; CANCER; DNA; SPECTROSCOPY; DIRECTIGEN

Citation

RSC ADVANCES, v.6, no.87, pp.84415 - 84419

ISSN
2046-2069
DOI
10.1039/c6ra13966c
URI
http://hdl.handle.net/10203/214152
Appears in Collection
CH-Journal Papers(저널논문)
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