Engineering of Bacterial Exotoxins for Highly Efficient and Receptor-Specific Intracellular Delivery of Diverse Cargos

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dc.contributor.authorRyou, Jeong-Hyunko
dc.contributor.authorSohn, Yoo-Kyoungko
dc.contributor.authorHwang, Da-Eunko
dc.contributor.authorPark, Woo Yongko
dc.contributor.authorKim, Nuryko
dc.contributor.authorHeo, Won Doko
dc.contributor.authorKim, Mi Youngko
dc.contributor.authorKim, Hak-Sungko
dc.date.accessioned2016-11-09T07:01:22Z-
dc.date.available2016-11-09T07:01:22Z-
dc.date.created2016-02-18-
dc.date.created2016-02-18-
dc.date.issued2016-08-
dc.identifier.citationBIOTECHNOLOGY AND BIOENGINEERING, v.113, no.8, pp.1639 - 1646-
dc.identifier.issn0006-3592-
dc.identifier.urihttp://hdl.handle.net/10203/213945-
dc.description.abstractThe intracellular delivery of proteins with high efficiency in a receptor-specific manner is of great significance in molecular medicine and biotechnology, but remains a challenge. Herein, we present the development of a highly efficient and receptor-specific delivery platform for protein cargos by combining the receptor binding domain of Escherichia coli Shiga-like toxin and the translocation domain of Pseudomonas aeruginosa exotoxin A. We demonstrated the utility and efficiency of the delivery platform by showing a cytosolic delivery of diverse proteins both in vitro and in vivo in a receptor-specific manner. In particular, the delivery system was shown to be effective for targeting an intracellular protein and consequently suppressing the tumor growth in xenograft mice. The present platform can be widely used for intracellular delivery of diverse functional macromolecules with high efficiency in a receptor-specific manner. (C) 2016 Wiley Periodicals, Inc.-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.subjectPSEUDOMONAS EXOTOXIN-
dc.subjectPROTECTIVE ANTIGEN-
dc.subjectPROTEIN DELIVERY-
dc.subjectANTHRAX TOXIN-
dc.subjectSHIGA TOXIN-
dc.subjectB-SUBUNIT-
dc.subjectCELLS-
dc.subjectTRANSLOCATION-
dc.subjectDOMAIN-
dc.subjectTERMINUS-
dc.titleEngineering of Bacterial Exotoxins for Highly Efficient and Receptor-Specific Intracellular Delivery of Diverse Cargos-
dc.typeArticle-
dc.identifier.wosid000384751100003-
dc.identifier.scopusid2-s2.0-84977103269-
dc.type.rimsART-
dc.citation.volume113-
dc.citation.issue8-
dc.citation.beginningpage1639-
dc.citation.endingpage1646-
dc.citation.publicationnameBIOTECHNOLOGY AND BIOENGINEERING-
dc.identifier.doi10.1002/bit.25935-
dc.contributor.localauthorHeo, Won Do-
dc.contributor.localauthorKim, Mi Young-
dc.contributor.localauthorKim, Hak-Sung-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorprotein engineering-
dc.subject.keywordAuthorprotein delivery-
dc.subject.keywordAuthorbacterial toxin-
dc.subject.keywordAuthorcytosolic delivery-
dc.subject.keywordAuthorintracellular delivery-
dc.subject.keywordPlusPSEUDOMONAS EXOTOXIN-
dc.subject.keywordPlusPROTECTIVE ANTIGEN-
dc.subject.keywordPlusPROTEIN DELIVERY-
dc.subject.keywordPlusANTHRAX TOXIN-
dc.subject.keywordPlusSHIGA TOXIN-
dc.subject.keywordPlusB-SUBUNIT-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusTRANSLOCATION-
dc.subject.keywordPlusDOMAIN-
dc.subject.keywordPlusTERMINUS-
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