Immune responses and immunopathology in acute and chronic viral hepatitis

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Hepatitis A virus (HAV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are responsible for most cases of viral hepatitis. Infection by each type of virus results in a different typical natural disease course and clinical outcome that are determined by virological and immunological factors. HCV tends to establish a chronic persistent infection, whereas HAV does not. HBV is effectively controlled in adults, although it persists for a lifetime after neonatal infection. In this Review, we discuss the similarities and differences in immune responses to and immunopathogenesis of HAV, HBV and HCV infections, which may explain the distinct courses and outcomes of each hepatitis virus infection
Publisher
NATURE PUBLISHING GROUP
Issue Date
2016-08
Language
English
Article Type
Review
Citation

NATURE REVIEWS IMMUNOLOGY, v.16, no.8, pp.509 - 523

ISSN
1474-1733
DOI
10.1038/nri.2016.69
URI
http://hdl.handle.net/10203/213085
Appears in Collection
MSE-Journal Papers(저널논문)
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