Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites

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Metabolic engineering using systems biology toots is increasingly applied to overproduce secondary metabolites for their potential industrial production. In this Highlight, recent relevant metabolic engineering studies are analyzed with emphasis on host selection and engineering approaches for the optimal production of various prokaryotic secondary metabolites: native versus heterologous hosts (e.g., Escherichia cols) and rational versus random approaches. This comparative analysis is followed by discussions on systems biology tools deployed in optimizing the production of secondary metabolites. The potential contributions of additional systems biology tools are also discussed in the context of current challenges encountered during optimization of secondary metabolite production
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2016-08
Language
English
Article Type
Review
Citation

NATURAL PRODUCT REPORTS, v.33, no.8, pp.933 - 941

ISSN
0265-0568
DOI
10.1039/c6np00019c
URI
http://hdl.handle.net/10203/213025
Appears in Collection
CBE-Journal Papers(저널논문)
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