Enhanced Neuronal Activity in the Medial Prefrontal Cortex during Social Approach Behavior

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Although the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little is known about mPFC neural correlates of social behavior. In the present study, we examined single-neuron activity in the mPFC of mice performing a modified version of the three-chamber test. We found that a subset of mPFC neurons elevate discharge rates when approaching a stranger mouse but not when approaching an inanimate object or an empty chamber. Our results reveal mPFC neural activity that is correlated with social approach behavior in a widely used social-interaction paradigm. These findings might be helpful for future investigations of mPFC neural processes underlying social interaction in health and disease
Publisher
SOC NEUROSCIENCE
Issue Date
2016-06
Language
English
Article Type
Article
Keywords

MICE; DISORDERS; DEFICITS; AUTISM; SCHIZOPHRENIA; PARVALBUMIN; HIPPOCAMPUS; INHIBITION; PHENOTYPES; RELEVANT

Citation

JOURNAL OF NEUROSCIENCE, v.36, no.26, pp.6926 - 6936

ISSN
0270-6474
DOI
10.1523/JNEUROSCI.0307-16.2016
URI
http://hdl.handle.net/10203/212406
Appears in Collection
BS-Journal Papers(저널논문)
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