Astrocytes Control Synapse Formation, Function, and Elimination

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Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of critical findings have highlighted the importance of astrocytes in the establishment of synaptic connectivity in the developing brain. In this article, we will review the key findings on astrocytic control of synapse formation, function, and elimination. First, we will summarize our current structural and functional understanding of astrocytes at the synapse. Then, we will discuss the cellular and molecular mechanisms through which developing and mature astrocytes instruct the formation, maturation, and refinement of synapses. Our aim is to provide an overview of astrocytes as important players in the establishment of a functional nervous system
Publisher
COLD SPRING HARBOR LAB PRESS
Issue Date
2015-02
Language
English
Article Type
Article
Keywords

DENDRITIC SPINE MORPHOLOGY; CELL CORPSE ENGULFMENT; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; GLIAL TNF-ALPHA; NEUROMUSCULAR-JUNCTION; EXCITATORY SYNAPSES; HIPPOCAMPAL-NEURONS; CNS SYNAPTOGENESIS; C-ELEGANS

Citation

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, v.7, no.9

ISSN
1943-0264
DOI
10.1101/cshperspect.a020370
URI
http://hdl.handle.net/10203/209076
Appears in Collection
BS-Journal Papers(저널논문)
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