A basal-like breast cancer-specific role for SRF-IL6 in YAP-induced cancer stemness

Cited 54 time in webofscience Cited 0 time in scopus
  • Hit : 323
  • Download : 526
The switch between stem/progenitor cell expansion and differentiation is critical for organ homeostasis. The mammalian Hippo pathway effector and oncoprotein YAP expands undifferentiated stem/progenitor cells in various tissues. However, the YAP-associated transcription factors and downstream targets underlying this stemness-promoting activity are poorly understood. Here we show that the SRF-IL6 axis is the critical mediator of YAP-induced stemness in mammary epithelial cells and breast cancer. Specifically, serum response factor (SRF)-mediated binding and recruitment of YAP to mammary stem cell (MaSC) signature-gene promoters induce numerous MaSC signature genes, among which the target interleukin (IL)-6 is critical for YAP-induced stemness. High SRF-YAP/TAZ expression is correlated with IL6-enriched MaSC/basal-like breast cancer (BLBC). Finally, we show that this high SRF expression enables YAP to more efficiently induce IL6 and stemness in BLBC compared with luminal-type breast cancer. Collectively, our results establish the importance of SRF-YAP-IL6 signalling in promoting MaSC-like properties in a BLBC-specific manner.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2015-12
Language
English
Article Type
Article
Citation

NATURE COMMUNICATIONS, v.6

ISSN
2041-1723
DOI
10.1038/ncomms10186
URI
http://hdl.handle.net/10203/207807
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
93752.pdf(2.45 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 54 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0