피부 재생능력 촉진을 위한 물리적 복합자극의 활용 연구 Combinatorial Physical Stimulation and Synergistically-Enhanced Fibroblast Differentiation for Skin Regeneration

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For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called “myofibroblasts” typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smooth-muscle actin (α-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch.
Publisher
한국정밀공학회
Issue Date
2015-08
Language
Korean
Citation

한국정밀공학회지, v.32, no.8, pp.755 - 760

ISSN
1225-9071
DOI
10.7736/KSPE.2015.32.8.755
URI
http://hdl.handle.net/10203/205395
Appears in Collection
ME-Journal Papers(저널논문)
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