Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy

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We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of similar to 10 nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-term in vivo survival study of WO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2015-11
Language
English
Article Type
Article
Keywords

HYALURONIC-ACID NANOPARTICLES; REDUCED GRAPHENE OXIDE; 980 NM-LASER; CARBON NANOPARTICLES; GOLD NANOPARTICLES; POLYMER; LIGHT; CHEMISTRY; ABLATION; DELIVERY

Citation

JOURNAL OF CONTROLLED RELEASE, v.217, pp.211 - 220

ISSN
0168-3659
DOI
10.1016/j.jconrel.2015.09.010
URI
http://hdl.handle.net/10203/205180
Appears in Collection
CH-Journal Papers(저널논문)
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