Cytomegalovirus Infection and Memory T Cell Inflation

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Cytomegalovirus (CMV) infection in healthy individuals is usually asymptomatic and results in latent infection. CMV reactivation occasionally occurs in healthy individuals according to their immune status over time. T cell responses to CMV are restricted to a limited number of immunodominant epitopes, as compared to responses to other chronic or persistent viruses. This response results in progressive, prolonged expansion of CMV-specific CD8+ T cells, termed ‘memory inflation’. The expanded CMVspecific CD8+ T cell population is extraordinarily large and is more prominent in the elderly. CMV-specific CD8+ T cells possess rather similar phenotypic and functional features to those of replicative senescent T cells. In this review, we discuss the general features of CMV-specific inflationary memory T cells and the factors involved in memory inflation.
Publisher
대한면역학회
Issue Date
2015-08
Language
English
Article Type
Review
Citation

IMMUNE NETWORK, v.15, no.4, pp.186 - 190

ISSN
1598-2629
DOI
10.4110/in.2015.15.4.186
URI
http://hdl.handle.net/10203/203536
Appears in Collection
MSE-Journal Papers(저널논문)
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