DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Seong-Hee | ko |
dc.contributor.author | Latif, Muhammad | ko |
dc.contributor.author | Qasim, Muhammad | ko |
dc.contributor.author | Choi, Sik-Won | ko |
dc.contributor.author | Lee, Joo Yun | ko |
dc.contributor.author | Byun, Byung Jin | ko |
dc.contributor.author | Saeed, Aamer | ko |
dc.contributor.author | Kim, Seong Hwan | ko |
dc.date.accessioned | 2016-04-12T08:14:08Z | - |
dc.date.available | 2016-04-12T08:14:08Z | - |
dc.date.created | 2015-10-06 | - |
dc.date.created | 2015-10-06 | - |
dc.date.issued | 2015-09 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.36, no.9, pp.2247 - 2253 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://hdl.handle.net/10203/203497 | - |
dc.description.abstract | Novel oxadiazoles bearing 5-phenyl-tetrazole (5a-k) were designed and efficiently synthesized by treating 2-(5-phenyl-2H-tetrazole-2-yl)acetohydrazide (4) with aromatic carboxylic acids in POCl3 , and their in vitro anti-osteoclastogenic activities were evaluated. In the cell-based osteoclast differentiation model, all compounds (5a-k) inhibited the formation of osteoclasts. In addition, the potential target molecules of compound 5 analogs were predicted with their chemical substructures via a web-based interface, and some of them were found to be related to osteoclast differentiation. Consequently, the scaffold containing oxadiazole-tetrazole in a single molecule and their analogs are of potential use in the design of novel anti-osteoclastogenic therapeutics. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | RECEPTOR ANTAGONISTS | - |
dc.subject | CANCER-CELLS | - |
dc.subject | GM-CSF | - |
dc.subject | BONE | - |
dc.subject | 1,3,4-OXADIAZOLE | - |
dc.subject | ANTIFUNGAL | - |
dc.subject | DESIGN | - |
dc.subject | FUSION | - |
dc.subject | POTENT | - |
dc.subject | AGENTS | - |
dc.title | Synthesis, Characterization, and Biological Evaluation of Oxadiazole Derivatives Bearing 5-Phenyl-tetrazole as Osteoclast Differentiation Inhibitors | - |
dc.type | Article | - |
dc.identifier.wosid | 000360918600013 | - |
dc.identifier.scopusid | 2-s2.0-84941599244 | - |
dc.type.rims | ART | - |
dc.citation.volume | 36 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 2247 | - |
dc.citation.endingpage | 2253 | - |
dc.citation.publicationname | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.1002/bkcs.10436 | - |
dc.contributor.nonIdAuthor | Moon, Seong-Hee | - |
dc.contributor.nonIdAuthor | Qasim, Muhammad | - |
dc.contributor.nonIdAuthor | Choi, Sik-Won | - |
dc.contributor.nonIdAuthor | Lee, Joo Yun | - |
dc.contributor.nonIdAuthor | Byun, Byung Jin | - |
dc.contributor.nonIdAuthor | Saeed, Aamer | - |
dc.contributor.nonIdAuthor | Kim, Seong Hwan | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Bone | - |
dc.subject.keywordAuthor | Osteoclastogenesis | - |
dc.subject.keywordAuthor | Oxadiazole | - |
dc.subject.keywordAuthor | Tetrazole | - |
dc.subject.keywordPlus | RECEPTOR ANTAGONISTS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | BONE | - |
dc.subject.keywordPlus | 1,3,4-OXADIAZOLE | - |
dc.subject.keywordPlus | ANTIFUNGAL | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | AGENTS | - |
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