Non-monotonic reorganization of brain networks with Alzheimer's disease progression

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Background: Identification of stage-specific changes in brain network of patients with Alzheimer's disease (AD# is critical for rationally designed therapeutics that delays the progression of the disease. However, pathological neural processes and their resulting changes in brain network topology with disease progression are not clearly known. Methods: The current study was designed to investigate the alterations in network topology of resting state fMRI among patients in three different clinical dementia rating #CDR# groups #i.e., CDR = 0.5, 1, 2# and amnestic mild cognitive impairment #aMCI# and age-matched healthy subject groups. We constructed density networks from these 5 groups and analyzed their network properties using graph theoretical measures. Results: The topological properties of AD brain networks differed in a non-monotonic, stage-specific manner. Interestingly, local and global efficiency and betweenness of the network were rather higher in the aMCI and AD #CDR 1) groups than those of prior stage groups. The number, location, and structure of rich-clubs changed dynamically as the disease progressed. Conclusions: The alterations in network topology of the brain are quite dynamic with AD progression, and these dynamic changes in network patterns should be considered meticulously for efficient therapeutic interventions of AD.
Publisher
FRONTIERS RESEARCH FOUNDATION
Issue Date
2015-06
Language
English
Article Type
Article
Keywords

MILD COGNITIVE IMPAIRMENT; GRAPH-THEORETICAL ANALYSIS; HIPPOCAMPAL ACTIVATION; COMPLEX NETWORKS; FMRI DATA; CONNECTIVITY; DIFFUSION; DIAGNOSIS; DEMENTIA; STATE

Citation

FRONTIERS IN AGING NEUROSCIENCE, v.7

ISSN
1663-4365
DOI
10.3389/fnagi.2015.00111
URI
http://hdl.handle.net/10203/200238
Appears in Collection
BiS-Journal Papers(저널논문)
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