High sensitivity nanoparticle detection using optical microcavities

Cited 195 time in webofscience Cited 0 time in scopus
  • Hit : 208
  • Download : 0
We demonstrate a highly sensitive nanoparticle and virus detection method by using a thermal-stabilized reference interferometer in conjunction with an ultrahigh-Q microcavity. Sensitivity is sufficient to resolve shifts caused by binding of individual nanobeads in solution down to a record radius of 12.5 nm, a size approaching that of single protein molecules. A histogram of wavelength shift versus nanoparticle radius shows that particle size can be inferred from shift maxima. Additionally, the signal-to-noise ratio for detection of Influenza A virus is enhanced to 38:1 from the previously reported 3:1. The method does not use feedback stabilization of the probe laser. It is also observed that the conjunction of particle- induced backscatter and optical-path-induced shifts can be used to enhance detection signal-to-noise.
Publisher
NATL ACAD SCIENCES
Issue Date
2011-04
Language
English
Article Type
Article
Keywords

WHISPERING-GALLERY MODES; SINGLE MOLECULES; MICROSPHERES; RESONATORS; SCATTERING; SHIFT

Citation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.108, no.15, pp.5976 - 5979

ISSN
0027-8424
DOI
10.1073/pnas.1017962108
URI
http://hdl.handle.net/10203/198986
Appears in Collection
NT-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 195 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0