Multi-stage continuous high cell density culture systems: A review

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dc.contributor.authorChang, Ho-Namko
dc.contributor.authorJung, Kwonsuko
dc.contributor.authorChoi, Jin-Dal-Raeko
dc.contributor.authorLee, Joon Chulko
dc.contributor.authorWoo, Hee-Chulko
dc.date.accessioned2015-04-06T05:47:00Z-
dc.date.available2015-04-06T05:47:00Z-
dc.date.created2014-11-24-
dc.date.created2014-11-24-
dc.date.issued2014-03-
dc.identifier.citationBIOTECHNOLOGY ADVANCES, v.32, no.2, pp.514 - 525-
dc.identifier.issn0734-9750-
dc.identifier.urihttp://hdl.handle.net/10203/194699-
dc.description.abstractA multi-stage continuous high cell density culture (MSC-HCDC) system makes it possible to achieve high productivity together with high product titer of many bioproducts. For long-term continuous operation of MSC-HCDC systems, the cell retention time and hydraulic retention time must be decoupled and strains (bacteria, yeast, plant, and animal cells) must be stable. MSC-HCDC systems are suitable for low-value high-volume extracellular products such as fuel ethanol, lactic acid or volatile fatty acids, and high-value products such as monoclonal antibodies as well as intracellular products such as polyhydroxybutyric acid (PHB), microbial lipids or a number of therapeutics. Better understanding of the fermentation kinetics of a specific product and reliable high-density culture methods for the product-generating microorganisms will facilitate timely industrialization of MSC-HCDC systems for products that are currently obtained in fed-batch bioreactors.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectFED-BATCH CULTURE-
dc.subjectHOLLOW-FIBER BIOREACTOR-
dc.subjectRECOMBINANT ANTIBODY-PRODUCTION-
dc.subjectFILTER PERFUSION SYSTEM-
dc.subjectETHANOL-PRODUCTION-
dc.subjectALCALIGENES-EUTROPHUS-
dc.subjectMEMBRANE BIOREACTORS-
dc.subjectRECYCLE BIOREACTOR-
dc.subjectIMMOBILIZED CELLS-
dc.subjectESCHERICHIA-COLI-
dc.titleMulti-stage continuous high cell density culture systems: A review-
dc.typeArticle-
dc.identifier.wosid000343640400022-
dc.identifier.scopusid2-s2.0-84895486224-
dc.type.rimsART-
dc.citation.volume32-
dc.citation.issue2-
dc.citation.beginningpage514-
dc.citation.endingpage525-
dc.citation.publicationnameBIOTECHNOLOGY ADVANCES-
dc.identifier.doi10.1016/j.biotechadv.2014.01.004-
dc.contributor.localauthorChang, Ho-Nam-
dc.contributor.nonIdAuthorLee, Joon Chul-
dc.contributor.nonIdAuthorWoo, Hee-Chul-
dc.type.journalArticleReview-
dc.subject.keywordAuthorMulti-stage continuous bioreactors-
dc.subject.keywordAuthorHigh cell density culture-
dc.subject.keywordAuthorProduct titer improvement-
dc.subject.keywordAuthorProductivity improvement-
dc.subject.keywordPlusFED-BATCH CULTURE-
dc.subject.keywordPlusHOLLOW-FIBER BIOREACTOR-
dc.subject.keywordPlusRECOMBINANT ANTIBODY-PRODUCTION-
dc.subject.keywordPlusFILTER PERFUSION SYSTEM-
dc.subject.keywordPlusETHANOL-PRODUCTION-
dc.subject.keywordPlusALCALIGENES-EUTROPHUS-
dc.subject.keywordPlusMEMBRANE BIOREACTORS-
dc.subject.keywordPlusRECYCLE BIOREACTOR-
dc.subject.keywordPlusIMMOBILIZED CELLS-
dc.subject.keywordPlusESCHERICHIA-COLI-
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