Cytoprotective Silica Coating of Individual Mammalian Cells through Bioinspired Silicification

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The cytoprotective coating of physicochemically labile mammalian cells with a durable material has potential applications in cell-based sensors, cell therapy, and regenerative medicine, as well as providing a platform for fundamental single-cell studies in cell biology. In this work, HeLa cells in suspension were individually coated with silica in a cytocompatible fashion through bioinspired silicification. The silica coating greatly enhanced the resistance of the HeLa cells to enzymatic attack by trypsin and the toxic compound poly(allylamine hydrochloride), while suppressing cell division in a controlled fashion. This bioinspired cytocompatible strategy for single-cell coating was also applied to NIH 3T3 fibroblasts and Jurkat cells.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2014-07
Language
English
Article Type
Article
Keywords

DIATOM BIOSILICA; CHLORELLA CELLS; GENE DELIVERY; LIVING CELLS; FUNCTIONALIZATION; POLYMERS; ENCAPSULATION; CYTOTOXICITY; VIABILITY; DESIGN

Citation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.53, no.31, pp.8056 - 8059

ISSN
1433-7851
DOI
10.1002/anie.201402280
URI
http://hdl.handle.net/10203/194191
Appears in Collection
CH-Journal Papers(저널논문)
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