Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice

Cited 22 time in webofscience Cited 0 time in scopus
  • Hit : 286
  • Download : 216
DC FieldValueLanguage
dc.contributor.authorAgrawal, Vijayendrako
dc.contributor.authorMaharjan, Sonyko
dc.contributor.authorKim, Kyeojinko
dc.contributor.authorKim, Nam-Jungko
dc.contributor.authorSon, Jiminko
dc.contributor.authorLee, Keunhoko
dc.contributor.authorChoi, Hyun-Jungko
dc.contributor.authorRho, Seung-Sikko
dc.contributor.authorAhn, Sunjooko
dc.contributor.authorWon, Moo-Hoko
dc.contributor.authorHa, Sang-Junko
dc.contributor.authorKoh, Gou Youngko
dc.contributor.authorKim, Young-Myeongko
dc.contributor.authorSuh, Young-Gerko
dc.contributor.authorKwon, Young-Guenko
dc.date.accessioned2014-12-16T01:01:28Z-
dc.date.available2014-12-16T01:01:28Z-
dc.date.created2014-07-07-
dc.date.created2014-07-07-
dc.date.issued2014-05-
dc.identifier.citationONCOTARGET, v.5, no.9, pp.2761 - 2777-
dc.identifier.issn1949-2553-
dc.identifier.urihttp://hdl.handle.net/10203/192715-
dc.description.abstractTumor blood vessels are leaky and immature, which causes inadequate blood supply to tumor tissues resulting in hypoxic microenvironment and promotes metastasis. Here we have explored tumor vessel modulating activity of Sac-1004, a recently developed molecule in our lab, which directly potentiates VE-cadherin-mediated endothelial cell junction. Sac-1004 could enhance vascular junction integrity in tumor vessels and thereby inhibit vascular leakage and enhance vascular perfusion. Improved perfusion enabled Sac-1004 to have synergistic anti-tumor effect on cisplatin-mediated apoptosis of tumor cells. Interestingly, characteristics of normalized blood vessels namely reduced hypoxia, improved pericyte coverage and decreased basement membrane thickness were readily observed in tumors treated with Sac-1004. Remarkably, Sac-1004 was also able to inhibit lung and lymph node metastasis in MMTV and B16BL6 tumor models. This was in correlation with a reduction in epithelial-to-mesenchymal transition of tumor cells with considerable diminution in expression of related transcription factors. Moreover, cancer stem cell population dropped substantially in Sac-1004 treated tumor tissues. Taken together, our results showed that direct restoration of vascular junction could be a significant strategy to induce normalization of tumor blood vessels and reduce metastasis.-
dc.languageEnglish-
dc.publisherIMPACT JOURNALS LLC-
dc.subjectTO-MESENCHYMAL TRANSITION-
dc.subjectBREAST-CANCER-
dc.subjectGROWTH-FACTOR-
dc.subjectVESSEL NORMALIZATION-
dc.subjectDIABETIC-RETINOPATHY-
dc.subjectBLOOD-VESSELS-
dc.subjectCELLS-
dc.subjectANGIOGENESIS-
dc.subjectPERMEABILITY-
dc.subjectOXYGENATION-
dc.titleDirect endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice-
dc.typeArticle-
dc.identifier.wosid000336966600035-
dc.identifier.scopusid2-s2.0-84901236251-
dc.type.rimsART-
dc.citation.volume5-
dc.citation.issue9-
dc.citation.beginningpage2761-
dc.citation.endingpage2777-
dc.citation.publicationnameONCOTARGET-
dc.contributor.localauthorKoh, Gou Young-
dc.contributor.nonIdAuthorAgrawal, Vijayendra-
dc.contributor.nonIdAuthorMaharjan, Sony-
dc.contributor.nonIdAuthorKim, Kyeojin-
dc.contributor.nonIdAuthorKim, Nam-Jung-
dc.contributor.nonIdAuthorSon, Jimin-
dc.contributor.nonIdAuthorLee, Keunho-
dc.contributor.nonIdAuthorChoi, Hyun-Jung-
dc.contributor.nonIdAuthorRho, Seung-Sik-
dc.contributor.nonIdAuthorAhn, Sunjoo-
dc.contributor.nonIdAuthorWon, Moo-Ho-
dc.contributor.nonIdAuthorHa, Sang-Jun-
dc.contributor.nonIdAuthorKim, Young-Myeong-
dc.contributor.nonIdAuthorSuh, Young-Ger-
dc.contributor.nonIdAuthorKwon, Young-Guen-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorVascular permeability-
dc.subject.keywordAuthorHypoxia-
dc.subject.keywordAuthorNormalization-
dc.subject.keywordAuthorEpithelial-to-mesenchymal transition-
dc.subject.keywordAuthorSac-1004-
dc.subject.keywordPlusTO-MESENCHYMAL TRANSITION-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusGROWTH-FACTOR-
dc.subject.keywordPlusVESSEL NORMALIZATION-
dc.subject.keywordPlusDIABETIC-RETINOPATHY-
dc.subject.keywordPlusBLOOD-VESSELS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusPERMEABILITY-
dc.subject.keywordPlusOXYGENATION-
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
86176.pdf(8.38 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 22 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0