A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues

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An efficient and practical method for the direct cross-coupling between quinolones and a range of azoles was developed via copper-mediated C-H functionalization. This synthetic strategy provides a convenient access to a variety of C3-heteroaryl quinolones, quinolinone, nalidixic acid, uracil, pyridone and chromone derivatives, which are prominent structural motifs in many biologically active compounds.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2014-08
Language
English
Article Type
Article
Keywords

CATALYZED DIRECT ARYLATION; C-H BONDS; LIGANDLESS CONDITIONS; KINASE INHIBITORS; GENERAL-METHOD; ARYL BROMIDES; AZOLES; ALKENYLATION; DERIVATIVES; COMPLEXES

Citation

ORGANIC & BIOMOLECULAR CHEMISTRY, v.12, no.30, pp.5719 - 5726

ISSN
1477-0520
DOI
10.1039/c4ob00939h
URI
http://hdl.handle.net/10203/190037
Appears in Collection
CH-Journal Papers(저널논문)
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