Microtubule-associated protein tau is essential for long-term depression in the hippocampus

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The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD.
Publisher
ROYAL SOC
Issue Date
2014-01
Language
English
Article Type
Article
Keywords

GLYCOGEN-SYNTHASE KINASE-3-BETA; DISEASE-LIKE PHOSPHORYLATION; PAIRED HELICAL FILAMENT; ALZHEIMERS-DISEASE; ENDOGENOUS TAU; LOCALIZATION; POTENTIATION; OLIGOMERS; BINDING; AGGREGATION

Citation

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, v.369, no.1633

ISSN
0962-8436
DOI
10.1098/rstb.2013.0144
URI
http://hdl.handle.net/10203/190013
Appears in Collection
BS-Journal Papers(저널논문)
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