Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity

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Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and diet-induced weight gain are diminished in the mutant mice.
Publisher
NATL ACAD SCIENCES
Issue Date
2013-12
Language
English
Article Type
Article
Citation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.110, no.51, pp.20575 - 20580

ISSN
0027-8424
DOI
10.1073/pnas.1320454110
URI
http://hdl.handle.net/10203/187350
Appears in Collection
BS-Journal Papers(저널논문)
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