Increased Frontomotor Oscillations During Tic Suppression in Children With Tourette Syndrome

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This work investigated whether Tourette syndrome patients exhibit alterations in neural oscillations during spontaneous expression and suppression of tics. Electroencephalograms (EEGs) were recorded from 9 medication-na < ve children with Tourette syndrome and 10 age-matched healthy subjects in resting conditions and during tic suppression. Their cortical oscillations were examined using the power spectral method and partial directed coherence. The authors found increased oscillations of broad frequency bands in the frontomotor regions of patients during tic expression, suggesting the involvement of aberrant cortical oscillations in Tourette syndrome. More significantly, prominent increases in theta oscillation in the prefrontal area and directed frontomotor interactions in the theta and beta bands were observed during tic suppression. Furthermore, the directed EEG interaction from the frontal to motor regions was positively correlated with the severity of tic symptoms. These findings suggest that the frontal to motor interaction of cortical oscillations plays a significant role in tic suppression.
Publisher
SAGE PUBLICATIONS INC
Issue Date
2013-05
Language
English
Article Type
Article
Keywords

TRANSCRANIAL MAGNETIC STIMULATION; ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER; OBSESSIVE-COMPULSIVE DISORDER; PARTIAL DIRECTED COHERENCE; SLOW CORTICAL POTENTIALS; HIGH-RESOLUTION EEG; FUNCTIONAL NEUROANATOMY; BRAIN OSCILLATIONS; COGNITIVE CONTROL; MOTOR INHIBITION

Citation

JOURNAL OF CHILD NEUROLOGY, v.28, no.5, pp.615 - 624

ISSN
0883-0738
DOI
10.1177/0883073812450317
URI
http://hdl.handle.net/10203/174761
Appears in Collection
BiS-Journal Papers(저널논문)
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