ENA Actimineral Resource A restores bone loss and bone quality in ovariectomized rats

Cited 3 time in webofscience Cited 3 time in scopus
  • Hit : 433
  • Download : 3
The purpose of this study was to examine the effects of ENA Actimineral Resource A (ENA-A), seaweed origin alkaline water, on postmenopausal osteoporosis in ovariectomized (OVX) rats. The 12-week old Wistar rats were divided randomly into 4 groups: ovariectomized (OVX), OVX plus 0.5% ENA-A, OVX plus 5% ENA-A and OVX plus 10% ENA-A. A histopathological analysis indicated that ENA-A could prevent OVX-induced bone loss by increasing femur trabecular bone area in a dose-dependent manner. ENA-A significantly (p < 0.05) increased serum estradiol levels, decreased serum osteocalcin activity and suppressed serum pyridinoline (PYD) levels. The in vitro effects of ENA-A were also studied using MC3T3-E1 cells. ENA-A significantly stimulated cell proliferation and increased both ALP activity and calcium deposition in a dose-dependent manner. These results suggest that the treatment of ovariectomized rats with ENA-A not only prevents bone resorption but also appears to maintain the cancellous bone structure of postmeopausal osteoporosis.
Publisher
SPRINGER
Issue Date
2007-01
Language
English
Article Type
Article
Keywords

BIOCHEMICAL MARKERS; POSTMENOPAUSAL OSTEOPOROSIS; SEX STEROIDS; CROSS-LINKS; TURNOVER; ESTROGEN; HORMONE; WOMEN; MASS; METABOLISM

Citation

MOLECULAR AND CELLULAR BIOCHEMISTRY, v.295, no.1-2, pp.35 - 43

ISSN
0300-8177
DOI
10.1007/s11010-006-9269-5
URI
http://hdl.handle.net/10203/17099
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 3 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0