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College of Natural Sciences(자연과학대학)Dept. of Chemistry(화학과)CH-Journal Papers(저널논문)

Antifungal mechanism of a cysteine-rich antimicrobial peptide, Ib-AMP1, from Impatiens balsamina against Candida albicans

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dc.contributor.authorLee, DGko
dc.contributor.authorShin, SYko
dc.contributor.authorKim, DHko
dc.contributor.authorSeo, MYko
dc.contributor.authorKang, JHko
dc.contributor.authorLee, Younghoonko
dc.contributor.authorKim, KLko
dc.contributor.authorHahm, KSko
dc.date.accessioned2009-09-29T07:18:13Z-
dc.date.available2009-09-29T07:18:13Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1999-12-
dc.identifier.citationBIOTECHNOLOGY LETTERS, v.21, no.12, pp.1047 - 1050-
dc.identifier.issn0141-5492-
dc.identifier.urihttp://hdl.handle.net/10203/11590-
dc.description.abstractThe antifungal mechanism of a 20-mer peptide, Ib-AMP1, derived from Impatiens balsamina was investigated. The oxidized (disulfide bridged) Ib-AMP1 showed a 4-fold increase in antifungal activity against Aspergillus flavus and Candida albicans than reduced (non-disulfide bridged) Ib-AMP1. Ib-AMP1 had very low activity for phospholipid disruption when compared with cecropin A(1-8)-magainin 2(1-12), a alpha-helical amphiphatic, antimicrobial peptide. Confocal microscopy showed that Ib-AMP1 binds on cell surface or penetrates into cell membranes. These results suggested that Ib-AMP1 may manifest its antifungal activity against Candida albicans by inhibiting a distinct cellular process rather than ion channel or pore formation in cell membrane.-
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherKLUWER ACADEMIC PUBL-
dc.subjectMAGAININ-2-
dc.subjectVESICLES-
dc.subjectPROTEIN-
dc.subjectHYBRID-
dc.titleAntifungal mechanism of a cysteine-rich antimicrobial peptide, Ib-AMP1, from Impatiens balsamina against Candida albicans-
dc.typeArticle-
dc.identifier.wosid000084811200004-
dc.identifier.scopusid2-s2.0-0033383178-
dc.type.rimsART-
dc.citation.volume21-
dc.citation.issue12-
dc.citation.beginningpage1047-
dc.citation.endingpage1050-
dc.citation.publicationnameBIOTECHNOLOGY LETTERS-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorLee, Younghoon-
dc.contributor.nonIdAuthorLee, DG-
dc.contributor.nonIdAuthorShin, SY-
dc.contributor.nonIdAuthorKim, DH-
dc.contributor.nonIdAuthorSeo, MY-
dc.contributor.nonIdAuthorKang, JH-
dc.contributor.nonIdAuthorKim, KL-
dc.contributor.nonIdAuthorHahm, KS-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorantifungal mechanism-
dc.subject.keywordAuthorCandida albicans-
dc.subject.keywordAuthorconfocal microscopy-
dc.subject.keywordAuthorIb-AMP1-
dc.subject.keywordPlusMAGAININ-2-
dc.subject.keywordPlusVESICLES-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusHYBRID-
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