Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules

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Phosphodiesterases (PDEs) are a superfamily of enzymes that degrade the intracellular second messengers cyclic AMP and cyclic GMP(1-3). As essential regulators of cyclic nucleotide signalling with diverse physiological functions, PDEs are drug targets for the treatment of various diseases, including heart failure, depression, asthma, inflammation and erectile dysfunction(4-7). Of the 12 PDE gene families, cGMP-specific PDE5 carries out the principal cGMP-hydrolysing activity in human corpus cavernosum tissue. It is well known as the target of sildenafil citrate (Viagra) and other similar drugs for the treatment of erectile dysfunction. Despite the pressing need to develop selective PDE inhibitors as therapeutic drugs, only the cAMP-specific PDE4 structures are currently available(8,9). Here we present the three-dimensional structures of the catalytic domain (residues 537-860) of human PDE5 complexed with the three drug molecules sildenafil, tadalafil (Cialis) and vardenafil (Levitra). These structures will provide opportunities to design potent and selective PDE inhibitors with improved pharmacological profiles.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2003-09
Language
English
Article Type
Article
Keywords

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; INHIBITORS; MECHANISM; COMPLEX

Citation

NATURE, v.425, no.6953, pp.98 - 102

ISSN
0028-0836
URI
http://hdl.handle.net/10203/11490
Appears in Collection
CH-Journal Papers(저널논문)
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