DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, J | ko |
dc.contributor.author | Churchill, David G | ko |
dc.contributor.author | Botta, M | ko |
dc.contributor.author | Raymond, KN | ko |
dc.date.accessioned | 2009-08-31 | - |
dc.date.available | 2009-08-31 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-09 | - |
dc.identifier.citation | INORGANIC CHEMISTRY, v.43, no.18, pp.5492 - 5494 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.uri | http://hdl.handle.net/10203/10859 | - |
dc.description.abstract | Prospective gadolinium(III) MRI contrast agent precursors [GdTREN-1,2-HOPO] (1) {TREN-1,2-HOPO = tris[(1-hydroxy-2-oxo-1,2-dihydropyridine-6-carboxamido)ethyl]amine} and [Gd-TREN-bis(Me-3,2-HOPO)-1,2-HOPO] (2) have been synthesized and characterized by relaxometric measurements. The water proton relaxivity values of 1 and 2 (20 MHz and 25 degreesC) are 9.5 and 9.3 mM(-1)s(-1), respectively, suggesting the presence of two coordinated water molecules. The molecular structure of [1.DMF](2) was obtained and reveals a similar eight-coordinate geometry to [Gd-TREN-Me-3,2-HOPO.2H(2)O] ([3.2H(2)O]). A shape analysis of the coordination polyhedron of 1 reveals that this geometry is best described as a bicapped trigonal prism, poised to accommodate an additional donor atom to give a tricapped trigonal prismatic intermediate. This geometry supports the model that formation of a tris-aquo intermediate for 1 enables fast and associative water exchange. | - |
dc.description.sponsorship | Support from the National Institutes of Health (Grant HL69832) | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | THERMODYNAMIC EVALUATION | - |
dc.subject | WATER-EXCHANGE | - |
dc.subject | LIGAND | - |
dc.subject | STABILITY | - |
dc.title | Gadolinium(III) 1,2-hydroxypyridonate-based complexes: Toward MRI contrast agents of high relaxivity | - |
dc.type | Article | - |
dc.identifier.wosid | 000223680200005 | - |
dc.identifier.scopusid | 2-s2.0-4444304936 | - |
dc.type.rims | ART | - |
dc.citation.volume | 43 | - |
dc.citation.issue | 18 | - |
dc.citation.beginningpage | 5492 | - |
dc.citation.endingpage | 5494 | - |
dc.citation.publicationname | INORGANIC CHEMISTRY | - |
dc.identifier.doi | 10.1021/ic049028s | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Churchill, David G | - |
dc.contributor.nonIdAuthor | Xu, J | - |
dc.contributor.nonIdAuthor | Botta, M | - |
dc.contributor.nonIdAuthor | Raymond, KN | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | THERMODYNAMIC EVALUATION | - |
dc.subject.keywordPlus | WATER-EXCHANGE | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | STABILITY | - |
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