A new cucurbit[6]uril-based ion-selective electrode for acetylcholine with high selectivity over choline and related quaternary ammonium ions

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Detection of acetylcholine (ACh(+)) with high sensitivity and selectivity in the presence of interfering ions including choline (Ch(+)) poses a significant analytical challenge. A cucurbit[6]uril derivative, (allyloxy)(12)CB[6], forms a stable 1:1 inclusion complex with ACh(+) but does not interact significantly with Ch(+) in solution. Based on this result, we prepared ion-selective electrodes (ISEs) for ACh(+) using (allyloxy)(12)CB[6] as an ionophore. The (allyloxy)(12)CB[6]-based ISEs detect ACh(+) with unprecedentedly high selectivity over Ch(+) as well as other interfering ions such as dopamine, NH4+, N(CH3)(4)(+) and N(CH2CH3)(4)(+).
Publisher
TAYLOR & FRANCIS LTD
Issue Date
2012
Language
English
Article Type
Article
Keywords

PHARMACEUTICAL-PREPARATION; BULK OPTODES; CUCURBITURIL; DERIVATIVES; MICRODIALYSIS; OPTIMIZATION; CHEMISTRY; MEMBRANE; RELEASE; SENSORS

Citation

SUPRAMOLECULAR CHEMISTRY, v.24, no.7, pp.487 - 491

ISSN
1061-0278
DOI
10.1080/10610278.2012.688125
URI
http://hdl.handle.net/10203/103759
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