Butanol production from renewable biomass: Rediscovery of metabolic pathways and metabolic engineering

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Biofuel from renewable biomass is one of the answers to help solve the problems associated with limited fossil resources and climate change. Butanol has superior liquid-fuel characteristics, with similar properties to gasoline, and thus, has the potential to be used as a substitute for gasoline. Clostridia are recognized as a good butanol producers and are employed in the industrial-scale production of solvents. Due to the difficulty of performing genetic manipulations on clostridia, however, strain improvement has been rather slow. Furthermore, complex metabolic characteristics of acidogenesis followed by solventogenesis in this strain have hampered the development of engineered clostridia strains with highly efficient and selective butanol-production capabilities. In recent years, the butanol-producing characteristics in clostridia have been further characterized and alternative pathways discovered. More recently, systems-level metabolic engineering approaches were taken to develop superior strains. Herein, we review recent discoveries of metabolic pathways for butanol production and the metabolic engineering strategies being developed.
Publisher
WILEY-BLACKWELL
Issue Date
2012-02
Language
English
Article Type
Review
Keywords

CLOSTRIDIUM-ACETOBUTYLICUM ATCC-824; BEIJERINCKII NCIMB 8052; ESCHERICHIA-COLI; BUTYRIBACTERIUM-METHYLOTROPHICUM; TRANSCRIPTIONAL PROGRAM; CONTINUOUS CULTURES; CARBON-MONOXIDE; FERMENTATIVE PRODUCTION; ENERGY-CONSERVATION; ANAEROBIC-BACTERIA

Citation

BIOTECHNOLOGY JOURNAL, v.7, no.2, pp.186 - 198

ISSN
1860-6768
DOI
10.1002/biot.201100059
URI
http://hdl.handle.net/10203/102802
Appears in Collection
CBE-Journal Papers(저널논문)
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