The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels

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TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and G alpha q protein coupled receptor or epidermal growth factor in particular. However, our understanding of the roles of G alpha i/o proteins on TRPC4/5 channels is still rudimentary. We discuss potential roles for G alpha i/o proteins in channel activation in addition to their known role in cellular signaling.
Publisher
LANDES BIOSCIENCE
Issue Date
2012-09
Language
English
Article Type
Article
Keywords

NONSELECTIVE CATION CHANNELS; PIG GASTRIC MYOCYTES; OPERATED CA2+ ENTRY; SMOOTH-MUSCLE-CELLS; VASCULAR ENDOTHELIAL CADHERIN; INTERSTITIAL-CELLS; CRAC CHANNEL; SURFACE EXPRESSION; CALCIUM-ENTRY; KINASE-C

Citation

CHANNELS, v.6, no.5, pp.333 - 343

ISSN
1933-6950
DOI
10.4161/chan.21198
URI
http://hdl.handle.net/10203/101808
Appears in Collection
RIMS Journal Papers
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