DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung, Hoon Ki | ko |
dc.contributor.author | Kim, Yong-Woon | ko |
dc.contributor.author | Choi, Soo Jeong | ko |
dc.contributor.author | Kim, Jong-Yeon | ko |
dc.contributor.author | Jeune, Kyung Hee | ko |
dc.contributor.author | Won, Kyu-Chang | ko |
dc.contributor.author | Kim, Jason K.) | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Park, So-Young | ko |
dc.date.accessioned | 2013-03-12T04:11:24Z | - |
dc.date.available | 2013-03-12T04:11:24Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v.297, pp.E402 - E409 | - |
dc.identifier.issn | 0193-1849 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101291 | - |
dc.description.abstract | Sung HK, Kim YW, Choi SJ, Kim JY, Jeune KH, Won KC, Kim JK, Koh GY, Park SY. COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice. Am J Physiol Endocrinol Metab 297: E402-E409, 2009. First published June 2, 2009; doi: 10.1152/ajpendo.00122.2009.-To test whether chronic enhanced blood flow alters insulin-stimulated glucose uptake, we measured skeletal muscle glucose uptake in chow-fed and high-fat-fed mice injected with adenovirus containing modified angiopoietin-1, COMP-Ang1, via euglycemic-hyperinsulinemic clamp. Blood flow rates and platelet endothelial cell adhesion molecule-1 positive endothelial cells in the hindlimb skeletal muscle were elevated in COMP-Ang1 compared with control LacZ. Whole body glucose uptake and whole body glycogen/lipid synthesis were elevated in COMP-Ang1 compared with LacZ in chow diet. High-fat diet significantly reduced whole body glucose uptake and whole body glycolysis in LacZ mice, whereas high-fat-fed COMP-Ang1 showed a level of whole body glucose uptake that was comparable with chow-fed LacZ and showed increased glucose uptake compared with high-fat-fed LacZ. Glucose uptake and glycolysis in gastrocnemius muscle of chow-fed COMP-Ang1 were increased compared with chow-fed LacZ. High-fat diet-induced whole body insulin resistance in the LacZ was mostly due to similar to 40% decrease in insulin-stimulated glucose uptake in skeletal muscle. In contrast, COMP-Ang1 prevented diet-induced skeletal muscle insulin resistance compared with high-fat-fed LacZ. Akt phosphorylation in skeletal muscle was increased in COMP-Ang1 compared with LacZ in both chow-fed and high-fat-fed groups. These results suggest that increased blood flow by COMP-Ang1 increases insulin-stimulated glucose uptake and prevents high-fat diet-induced insulin resistance in skeletal muscle. | - |
dc.language | English | - |
dc.publisher | AMER PHYSIOLOGICAL SOC | - |
dc.subject | MEDIATED CAPILLARY RECRUITMENT | - |
dc.subject | GLUCOSE-UPTAKE | - |
dc.subject | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject | TIE2 RECEPTOR | - |
dc.subject | HIGH-FAT | - |
dc.subject | IN-VIVO | - |
dc.subject | RESISTANCE | - |
dc.subject | DYSFUNCTION | - |
dc.subject | EXPRESSION | - |
dc.subject | VASCULARIZATION | - |
dc.title | COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000268252700015 | - |
dc.identifier.scopusid | 2-s2.0-68049094930 | - |
dc.type.rims | ART | - |
dc.citation.volume | 297 | - |
dc.citation.beginningpage | E402 | - |
dc.citation.endingpage | E409 | - |
dc.citation.publicationname | AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | - |
dc.identifier.doi | 10.1152/ajpendo.00122.2009 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Sung, Hoon Ki | - |
dc.contributor.nonIdAuthor | Kim, Yong-Woon | - |
dc.contributor.nonIdAuthor | Choi, Soo Jeong | - |
dc.contributor.nonIdAuthor | Kim, Jong-Yeon | - |
dc.contributor.nonIdAuthor | Jeune, Kyung Hee | - |
dc.contributor.nonIdAuthor | Won, Kyu-Chang | - |
dc.contributor.nonIdAuthor | Kim, Jason K.) | - |
dc.contributor.nonIdAuthor | Park, So-Young | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | glucose uptake | - |
dc.subject.keywordAuthor | high-fat diet | - |
dc.subject.keywordAuthor | hyperinsulinemic-euglycemic clamp | - |
dc.subject.keywordPlus | MEDIATED CAPILLARY RECRUITMENT | - |
dc.subject.keywordPlus | GLUCOSE-UPTAKE | - |
dc.subject.keywordPlus | OVEREXPRESSING ANGIOPOIETIN-1 | - |
dc.subject.keywordPlus | TIE2 RECEPTOR | - |
dc.subject.keywordPlus | HIGH-FAT | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | VASCULARIZATION | - |
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