T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

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Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelial growth factors secreted by B cells, macrophages, and dendritic cells (DCs). Here, we show that LNLV formation was negatively regulated by T cells. In both steady and inflammatory states, the density of LNLVs was increased in the absence of T cells but decreased when T cells were restored. Interferon-gamma secretion by T cells suppressed lymphatic-specific genes in lymphatic endothelial cells and consequently caused marked reduction in LNLV formation. When T cells were depleted, recruitment of antigen-carrying DCs to LNs was augmented, reflecting a compensatory mechanism for antigen presentation to T cells through increased LNLVs. Thus, T cells maintain the homeostatic balance of LNLV density through a negative paracrine action of interferon-gamma.
Publisher
CELL PRESS
Issue Date
2011-01
Language
English
Article Type
Article
Keywords

IFN-GAMMA; INTERFERON-GAMMA; INDUCED LYMPHANGIOGENESIS; ANTIGEN PRESENTATION; ENDOTHELIAL-CELLS; INFLAMMATION; MECHANISMS; SYSTEM; VEGF; VASCULATURE

Citation

IMMUNITY, v.34, no.1, pp.96 - 107

ISSN
1074-7613
URI
http://hdl.handle.net/10203/101244
Appears in Collection
MSE-Journal Papers(저널논문)
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