Fabrication of Alternating Multilayer Films of Graphene Oxide and Carbon Nanotube and Its Application in Mechanistic Study of Laser Desorption/Ionization of Small Molecules

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Graphene, graphene oxide (GO), and multi-walled carbon nanotube (MWCNT) have been actively explored as matrix for laser desorption/ionization mass spectrometry (LDI-MS) in place of conventional organic matrix. Recently, the GO/MWCNT double layer films on a solid substrate showed excellent applicability in small molecule analysis, enzyme activity assay and tissue imaging. In the present study, LDI processes of small molecules on multilayers of alternating MWCNT and GO hybrid films were thoroughly investigated. We found that the LDI efficiency of small molecules was affected by thickness, assembly sequence and surface roughness of the hybrid films that were controlled by varying the number of layer-by-layer (LBL) assembly cycles. The study would provide useful basic information to develop an efficient LDI-MS platform based on carbon nanomaterials.
Publisher
AMER CHEMICAL SOC
Issue Date
2012-04
Language
English
Article Type
Article
Keywords

FLIGHT MASS-SPECTROMETRY; MALDI-TOF-MS; DESORPTION-IONIZATION; GOLD NANOPARTICLES; SILICON DIOS; MATRIX; SURFACE; BIOMOLECULES; PEPTIDES; PROTEINS

Citation

ACS APPLIED MATERIALS & INTERFACES, v.4, no.4, pp.2088 - 2095

ISSN
1944-8244
DOI
10.1021/am300054z
URI
http://hdl.handle.net/10203/101120
Appears in Collection
CH-Journal Papers(저널논문)
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